PIKing the Right Patient: Fig. 1.

PIKing the right patient.

HER2 amplification and PIK3CA mutation were validated as biomarkers for sensitivity to the single-agent phosphoinositide 3-kinase (PI3K) inhibitor, GDC-0941, in breast cancer models. A novel expression profile was developed to identify other breast cancers sensitive to PI3K inhibitors. These expression studies highlighted feedback networks connecting TORC1, PI3K, and mitogen-activated protein k...

Fig. 1

Airway Inflammatory Biomarker: Could It Tailor the Right Medications for the Right Asthmatic Patient?

Asthma is a heterogeneous disease, in which asthmatic patients present with different clinical phenotypes, variable endotypes, and different response to asthma medicines. Thus, we are faced with an asthma paradox; asthma is diagnosed subjectively by clinical history and treated with biologically active drugs. To solve this paradox, we need objective airway biomarkers to tailor the proper medica...

Fig. 1: Mpeg-4 Coding Scheme

A programmable processor architecture for MPEG-4 video is proposed, that can serve as a coprocessor module in MPEG-4 decoder systems. It consists of a 64-bit dual-issue VLIW macroblock engine, a separate RISC core for bitstream parsing and system processing, and an autonomous I/O processor. A separate DSP is used for MPEG audio support. The architecture is fully programmable and supports parall...

Asthma Control: The Right Inhaler for the Right Patient

Inhaled therapy is the cornerstone of asthma management in that it optimizes the delivery of the medication to the site of action. The effectiveness of inhaled therapy is affected by the correct choice of the device and proper inhalation technique. In fact, this influences the drug delivery and distribution along the bronchial tree, including the most peripheral airways. In this context, accumu...